NIDA Small Research Grant Program (R03 Clinical Trial Required)

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    Funder Type

    Federal Government

    IT Classification

    B - Readily funds technology as part of an award


    National Institutes of Health (NIH)


    The NIDA Small Research Grant Program supports discrete, well-defined NIH defined clinical trials that realistically can be completed in two years and that require limited levels of funding. NIH Defines a clinical trial as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes” It includes mechanistic, exploratory/development, pilot/feasibility, behavioral and other interventions.

    This program supports different types of small clinical trials including, but not limited to, the following:

    • Medications.
    • Immunotherapies
    • Behavioral therapies
    • Therapeutic Devices
    • Therapeutic Digital Applications
    • Prevention Interventions
    • Health Services Interventions Development of research methodology or technology

    History of Funding

    None is avaialble.

    Additional Information

    Special Considerations

    National Advisory Council on Drug Abuse Recommended Guidelines for the Administration of Drugs to Human Subjects: The National Advisory Council on Drug Abuse (NACDA) recognizes the importance of research involving the administration of drugs with abuse potential, and dependence or addiction liability, to human subjects. Potential applicants are encouraged to obtain and review these recommendations of Council before submitting an application that will administer compounds to human subjects. The guidelines are available on NIDA's Web site at

    Points to Consider Regarding Tobacco Industry Funding of NIDA Applicants: The National Advisory Council on Drug Abuse (NACDA) encourages NIDA and its grantees to consider the points it has set forth with regard to existing or prospective sponsored research agreements with tobacco companies or their related entities and the impact of acceptance of tobacco industry funding on NIDA's credibility and reputation within the scientific community. Please see ( for details.

    Data Harmonization for Substance Abuse and Addiction via the PhenX Toolkit: NIDA strongly encourages investigators involved in human-subject studies to employ a common set of tools and resources that will promote the collection of comparable data across studies and to do so by incorporating the measures from the Core and Specialty collections, which are available in the Substance Abuse and Addiction Collection of the PhenX Toolkit ( Please see NOT-DA-12-008 ( for further details.


    Pam Fleming

    Pam Fleming
    National Institute on Drug Abuse (NIDA)
    9000 Rockville Pike
    Bethesda, MD 20892
    (301) 253-8729

  • Eligibility Details

    Eligible applicants are:

    • Higher Education Institutions
    • Nonprofits 
    • For-Profit Organizations
    • Governments
    • Native American Tribal Organizations
    • Non-domestic (non-U.S.) Entities (Foreign Institutions)

    Deadline Details

    Applications are to be submitted by February 16, June 16, and October 16, annually. AIDS and AIDS-Related Applications are to be submitted by May 7, September 7, and January 7, annually.

    Award Details

    Award amounts vary. Maximum award is $50,000. The total project period may not exceed two years. Cost sharing/matching is not required.

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